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KMID : 0384119960160030295
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Korean Journal of Clinical Pathology
1996 Volume.16 No. 3 p.295 ~ p.300
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A Case of Prolymphocytic Leukemia.
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문진영
조희순/이채훈/김경동/김정숙
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Abstract
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Prolymphocytic leukemia(PLL) is one of the chronic lymphoproliferative disorders which are characterized by the neoplastic proliferation of lymphoid cells that are capable of maturation.
It is an uncommon form of leukemia which represent either de novo leukemia or transformation of chronic lymphocytic leukemia, and is characterized by leukocytosis, massive splenomegaly with little or no lymphadenopathy, anemia, thrombocytopenia
and
male
prevalence, In order to make diagnosis of this disorder, more than 55% of prolymphocytes in the peripheral blood is required. In immunophenotyping, the majority(80%) of the cases express B cell marker and approximately 20%, T cell type. We
present
a
case of B-prolymphocytic leukemia with a review of the literatures. The patient was a 75 year-old man who presented with marked leukocytosis(84.5×10E9/L) with 62% of characteristic prolymphocyte in the peripheral blood, The immunophenotyping of
the
leukemic prolymphocytes revealed HLA-DR 90%, CD19 85%, CD5 72%, SIg 40%, and ectopic CD14 30%(Korean J Clin Pathol 1996;16(3):295~300).
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KEYWORD
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